Elucidating the Optimal Dosing Regimen of Intravenous Vitamin C for Improving Circulatory Management and Reversing Brain and Kidney Injury in Septic Shock

Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis. Response to Br J Anaesth 2026; 136: 781-2.

Clive N May, Mark P Plummer, Yugeesh R Lankadeva

2026-05-01

Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis

Clive N May, Connie P Ow, Ruslan Pustovit, Darius J Lane, Alemayehu H Jufar, Anton Trask-Marino, Rachel M Peiris, Adam Gunn, Lindsea C Booth, Mark P Plummer, Rinaldo Bellomo, Yugeesh R Lankadeva

2024-08-01

Background: The mechanisms by which megadose sodium ascorbate improves clinical status in experimental sepsis is unclear. We deter..